9P5C

Crystal structure of MLH1-CTD with CHDI-00916630

Summary for 9P5C

Entry DOI	10.2210/pdb9p5c/pdb
Descriptor	DNA mismatch repair protein Mlh1, CHDI-00916630 (3 entities in total)
Functional Keywords	mlh1, mismatch repair, dna repair, dna binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	60861.13
Authors	Zhu, G.,Koszelak-Rosenblum, M. (deposition date: 2025-06-18, release date: 2026-06-24)
Primary citation	Haque, T.S.,Orvieto, F.,Tomaselli, S.,Turcano, L.,De Simone, D.,Francone, A.,Micaelli, M.,Movetti, S.,Piacenti, V.,Gambini, L.,Alli, C.,Fodale, V.,Bianchi, E.,Toniatti, C.,Kawahara, D.,Ghosh, S.,Koszelak-Rosenblum, M.,Zhu, G.,Kintzel, S.,Williams, D.,Larocque, J.,Thieulin-Pardo, G.,Thomsen, M.,Dominguez, C.,Iyer, R.R.,Finley, M.,Felsenfeld, D.,Boudet, J.,Monteagudo, E.,Vogt, T.F.,Prasad, B.C. Cyclic Peptide Inhibitors of the MLH1-MSH3 Interaction as a Potential Therapeutic Strategy for Huntington's Disease Chemrxiv, 2026:-, Cited by DOI: 10.26434/chemrxiv.15000289/v2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation