9P4B

Crystal structure of MLH1-CTD with peptide QAVLSRFFQ

Summary for 9P4B

• Entry DOI: 10.2210/pdb9p4b/pdb
• Descriptor: DNA mismatch repair protein Mlh1, DNA mismatch repair protein Msh3 (3 entities in total)
• Functional Keywords: mlh1, mismatch repair, dna repair, dna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 64618.49

Authors

Zhu, G.,Koszelak-Rosenblum, M. (deposition date: 2025-06-16, release date: 2026-06-24)

• Primary citation: Haque, T.S.,Orvieto, F.,Tomaselli, S.,Turcano, L.,De Simone, D.,Francone, A.,Micaelli, M.,Movetti, S.,Piacenti, V.,Gambini, L.,Alli, C.,Fodale, V.,Bianchi, E.,Toniatti, C.,Kawahara, D.,Ghosh, S.,Koszelak-Rosenblum, M.,Zhu, G.,Kintzel, S.,Williams, D.,Larocque, J.,Thieulin-Pardo, G.,Thomsen, M.,Dominguez, C.,Iyer, R.R.,Finley, M.,Felsenfeld, D.,Boudet, J.,Monteagudo, E.,Vogt, T.F.,Prasad, B.C.; Cyclic Peptide Inhibitors of the MLH1-MSH3 Interaction as a Potential Therapeutic Strategy for Huntington's Disease; Chemrxiv, 2026:-, ; DOI: 10.26434/chemrxiv.15000289/v2

Experimental method

X-RAY DIFFRACTION (2.44 Å)