9P45

Crystal structure of KRAS-G12D (GMPPNP-bound) in complex with BBO-11818

This is a non-PDB format compatible entry.

Summary for 9P45

• Entry DOI: 10.2210/pdb9p45/pdb
• Descriptor: Isoform 2B of GTPase KRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: kras, ras, k-ras, kras4b, inhibitor, bbo-11818, bbo11818, bbo, theras, bridgebio, oncoprotein, oncoprotein-inhibitor complex, oncoprotein/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 20675.31

Authors

Chan, A.H.,Bratcher, D.R.,Simanshu, D.K. (deposition date: 2025-06-16, release date: 2025-12-03)

• Primary citation: Maciag, A.E.,Chan, A.H.,Simanshu, D.K.,Beltran, P.J.; Discovery of BBO-11818, a Potent and Selective Non-covalent Inhibitor of (ON) and (OFF) KRAS with Activity Against Multiple Oncogenic Mutants; Cancer Discov, 2025

Experimental method

X-RAY DIFFRACTION (1.35 Å)