9OUJ

K-Ras G12D 1-169 bound to MRTX-1133 at 310 K

Summary for 9OUJ

• Entry DOI: 10.2210/pdb9ouj/pdb
• Descriptor: Isoform 2B of GTPase KRas, 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: gtpase, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 40751.64

Authors

Xu, M.,Deck, S.L.,Milano, S.K.,Cerione, R.A. (deposition date: 2025-05-28, release date: 2026-06-17)

• Primary citation: Xu, M.,Deck, S.L.,Milano, S.K.,Cerione, R.A.; Oncogenic Mutants of Ras bound to Inhibitors at Various Temperatures; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.89 Å)