9OTX

Cryo-EM structure of the Substrate-bound clpXP complex (clpX harbors the Q208A mutation in subunits B, D, and F), Class-III

Summary for 9OTX

• Entry DOI: 10.2210/pdb9otx/pdb
• EMDB information: 70861
• Descriptor: ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, Substrate, ... (7 entities in total)
• Functional Keywords: translocation, protein unfolding, clpxp, translocase
• Biological source: Escherichia coli; More
• Total number of polymer chains: 21
• Total formula weight: 607195.74

Authors

Florez Ariza, A.J.,Sosa, R.,Bustamante, C. (deposition date: 2025-05-27, release date: 2026-10-28)

• Primary citation: Sosa, R.P.,Florez Ariza, A.J.,Kim, J.,Tong, A.B.,Kang, Z.H.,Li, A.,Kuriyan, J.,Bustamante, C.; The central coupler of ClpXP controls intersubunit communication and couples intrasubunit chemical energy with force generation; Nat Commun, 2026; DOI: 10.1038/s41467-026-78225-1

Experimental method

ELECTRON MICROSCOPY (3.4 Å)