9OHM

Cryo-EM structure of bovine phosphodiesterase 6 bound to CB-5083

Summary for 9OHM

• Entry DOI: 10.2210/pdb9ohm/pdb
• EMDB information: 70500
• Descriptor: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ... (7 entities in total)
• Functional Keywords: gaf domain, phosphohydrolase, g protein-coupled receptor signaling, signaling protein, cb-5083
• Biological source: Bos taurus (domestic cattle); More
• Total number of polymer chains: 4
• Total formula weight: 218976.68

Authors

Crawford, J.,Munuganti, R.,Leung, C.,Singh, K.,Gates, E.,Zhu, X.,Bally, M.,Dos Santos, N.,Sharifiaghdam, M.,Nosrati, Z.,Axerio-Cilies, P.,Berezuk, A.,Cholak, S.,Cameron, D.,Subramaniam, S. (deposition date: 2025-05-05, release date: 2026-05-27)

• Primary citation: Crawford, J.,Munuganti, R.,Leung, C.,Singh, K.,Gates, E.,Zhu, X.,Bally, M.,Dos Santos, N.,Sharifiaghdam, M.,Nosrati, Z.,Axerio-Cilies, P.,Berezuk, A.,Cholak, S.,Cameron, D.,Subramaniam, S.; Cryo-EM-guided subtractive optimization of a novel VCP/p97 inhibitor; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.72 Å)