9OGC

Cryo-EM structure of human exportin-1 conjugated with KPT-185 and bound to human ASB8-ELOB/C

Summary for 9OGC

• Entry DOI: 10.2210/pdb9ogc/pdb
• EMDB information: 70461
• Descriptor: Exportin-1, Ankyrin repeat and SOCS box protein 8, Elongin-C, ... (5 entities in total)
• Functional Keywords: nuclear export, inhibitor, protein degradation, protein transport
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 178011.37

Authors

Wing, C.E.,Fung, H.Y.J.,Chook, Y.M. (deposition date: 2025-04-30, release date: 2025-11-26)

• Primary citation: Wing, C.E.,Fung, H.Y.J.,Kwanten, B.,Cagatay, T.,Niesman, A.B.,Jacquelyn, M.,Gharghabi, M.,Permentier, B.,Shakya, B.,Ready, J.M.,Kashyap, T.,Shacham, S.,Landesman, Y.,Lapalombella, R.,Daelemans, D.,Chook, Y.M.; SINE compounds activate exportin-1 degradation via an allosteric mechanism; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.37 Å)