9ODX

Structure of Unc119B in complex with N-acetyl-S-geranylgeranyl-L-Cysteine

Summary for 9ODX

Entry DOI	10.2210/pdb9odx/pdb
Descriptor	Protein unc-119 homolog B, N-acetyl-S-geranylgeranyl-L-cysteine, SULFATE ION, ... (4 entities in total)
Functional Keywords	unc119, transport protein, lipid binding protein
Biological source	Mus musculus (house mouse)
Total number of polymer chains	1
Total formula weight	26503.80
Authors	Srivastava, D.,Sebag, J.A.,Artemyev, N.O. (deposition date: 2025-04-28, release date: 2025-09-03)
Primary citation	Mittal, A.,Buscaglia, P.,Srivastava, D.,Artemyev, N.O.,Sebag, J.A. Inhibition of Unc119b improves insulin sensitivity through potentiation of Rac1 activation in skeletal muscle and brown adipose tissue. Mol Metab, 100:102230-102230, 2025 Cited by PubMed Abstract: A hallmark of type II diabetes is an impairment of the glucose transporter GLUT4 translocation to the plasma membrane of specialized cells in response to insulin. Identifying mechanisms involved in this defect is critical to developing treatments that restore insulin sensitivity. We previously identified a small molecule insulin sensitizer, C59, which improves insulin-stimulated GLUT4 translocation through binding to Unc119b, however, the role and mechanism of Unc119b-mediated regulation of GLUT4 trafficking is unknown. PubMed: 40754229 DOI: 10.1016/j.molmet.2025.102230 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation