9OBD

Crystal structure of human Argonaute2 in complex with a fully modified siRNA with a 5'-phenylpropargyl phosphate

This is a non-PDB format compatible entry.

Summary for 9OBD

• Entry DOI: 10.2210/pdb9obd/pdb
• Descriptor: Protein argonaute-2, fully modified siRNA with a 5' phenylpropargyl phosphate, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: ago2, sirna, phosphorothioate, hydrolase, rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 104985.72

Authors

Gebert, L.F.R.,MacRae, I.J. (deposition date: 2025-04-22, release date: 2026-04-29, Last modification date: 2026-07-01)

• Primary citation: Gebert, L.F.R.,MacRae, I.J.; Discovery of Argonaute2 compatible 5'-Alkylated phosphate stabilization chemistry for siRNA guide strand; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.02 Å)