9OBB

Crystal structure of dihydroorotate dehydrogenase from Leishmania brasiliensis in complex with 5-[(E)-3-(p-methoxyphenyl)-2-propenylidene]-2,4,6(1H,3H,5H)-pyrimidinetrione

Summary for 9OBB

• Entry DOI: 10.2210/pdb9obb/pdb
• Descriptor: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, 5-[3-(4-methoxyphenyl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione, ... (4 entities in total)
• Functional Keywords: covalent inhibitor, dhodh, oxireductase, oxidoreductase
• Biological source: Leishmania braziliensis
• Total number of polymer chains: 2
• Total formula weight: 76260.78

Authors

Vaidergorn, M.M.,Nonato, M.C.,Froes, T.Q.,Augusto, B.S. (deposition date: 2025-04-22, release date: 2026-05-06)

• Primary citation: Vaidergorn, M.M.,Nonato, M.C.,Froes, T.Q.,Augusto, B.S.; Crystal structure of dihydroorotate dehydrogenase from Leishmania brasiliensis in complex with 5-[(E)-3-(p-methoxyphenyl)-2-propenylidene]-2,4,6(1H,3H,5H)-pyrimidinetrione; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.32 Å)