9O7I

CHIP E3 ligase CC domain dimer-Fab 2D2 epitope focused refinement

Summary for 9O7I

• Entry DOI: 10.2210/pdb9o7i/pdb
• EMDB information: 70200
• Descriptor: E3 ubiquitin-protein ligase CHIP, 2D2 Fab light chain, 2D2 Fab heavy chain (3 entities in total)
• Functional Keywords: u-box e3 ligase, fab, cryo-em, protein degradation, ligase-immune system complex, ligase/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 64526.23

Authors

Unnikrishnan, A.,Southworth, D. (deposition date: 2025-04-15, release date: 2026-05-13)

• Primary citation: Unnikrishnan, A.,Southworth, D.; Structures of Fab-stabilized CHIP reveal a conformational switch important in E3 ligase and chaperone functions; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.4 Å)