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9O51

Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex in the Ca2+ free state

Summary for 9O51
Entry DOI10.2210/pdb9o51/pdb
Related9O48
EMDB information70120
DescriptorIntermediate conductance calcium-activated potassium channel protein 4,Small conductance calcium-activated potassium channel protein 2 chimera, Calmodulin-1, POTASSIUM ION, ... (4 entities in total)
Functional Keywordsion channel, calcium, potassium, calmodulin, transport protein
Biological sourceHomo sapiens (human)
More
Total number of polymer chains8
Total formula weight265177.34
Authors
Cassell, S.J.,Khoshouei, M.,Wilhelm, W.A.,Whicher, J.R. (deposition date: 2025-04-09, release date: 2025-07-09)
Primary citationCassell, S.J.,Li, W.,Krautwald, S.,Khoshouei, M.,Lee, Y.T.,Hou, J.,Guan, W.,Peukert, S.,Wilhelm, W.A.,Whicher, J.R.
Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules
To Be Published,
Experimental method
ELECTRON MICROSCOPY (3.4 Å)
Structure validation

238895

数据于2025-07-16公开中

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