9O3Y

Human 80S ribosome bound to IDB-002 stalled on FPAK-containing nascent chain

This is a non-PDB format compatible entry.

Summary for 9O3Y

• Entry DOI: 10.2210/pdb9o3y/pdb
• EMDB information: 70083 70084 70085 70086
• Descriptor: 28S rRNA, Large ribosomal subunit protein eL8, Large ribosomal subunit protein uL6, ... (90 entities in total)
• Functional Keywords: translation inhibitor, interdictor, ribosome, cryogenic-electron microscopy (cryo-em), ribotoxic stress response, cancer, myc, translation
• Biological source: Homo sapiens; More
• Total number of polymer chains: 82
• Total formula weight: 3834124.00

Authors

Sauer, P.V.,Schuller, A.P.,Hamann, L.G. (deposition date: 2025-04-07, release date: 2026-03-04)

• Primary citation: Sauer, P.V.,Diamond, P.D.,Holm, M.,Swanson-Swett, C.J.,Ferguson, L.,Bratset, N.M.,Wienker, G.W.,Sim, J.S.,Adams, H.K.,Kenner, L.,Meyers, M.,Gygi, D.,Konst, Z.A.,Bahmanyar, S.S.,Hamann, L.G.,Schuller, A.P.; Context-dependent translation inhibition as a novel oncology therapeutic modality; Nat Commun, 2026; DOI: 10.1038/s41467-026-69891-2

Experimental method

ELECTRON MICROSCOPY (2.2 Å)