9NWX

Discovery of a Small Molecule ITK and Pan-TRK Kinase Inhibitor (PF-07245303) for the Potential Topical Treatment of Atopic Dermatitis

This is a non-PDB format compatible entry.

Summary for 9NWX

• Entry DOI: 10.2210/pdb9nwx/pdb
• Descriptor: Tyrosine-protein kinase ITK/TSK, (2S)-N-methyl-N-{6-methyl-2-[(4aS,5aR)-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazol-3-yl]-1H-1,3-benzimidazol-5-yl}-2-(morpholin-4-yl)propanamide (3 entities in total)
• Functional Keywords: kinase, inhibitor, atopic dermatitis, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 31097.57

Authors

Liu, S. (deposition date: 2025-03-24, release date: 2025-11-19)

• Primary citation: Liu, S.; Discovery of a Small Molecule ITK and Pan-TRK Kinase Inhibitor (PF-07245303) for the Potential Topical Treatment of Atopic Dermatitis; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.348 Å)