9NTP

EGFR kinase domain (T790MV948R) in complex with a strain-release covalent inhibitor

This is a non-PDB format compatible entry.

Summary for 9NTP

• Entry DOI: 10.2210/pdb9ntp/pdb
• Descriptor: Epidermal growth factor receptor, 1,2-ETHANEDIOL, N-[4-(3-chloro-4-fluoroanilino)-7-{[(3S)-oxolan-3-yl]oxy}quinazolin-6-yl]cyclobutanesulfonamide, ... (4 entities in total)
• Functional Keywords: covalent, inhibitor, complex, cancer, mutation, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38287.68

Authors

Schonbrunn, E.,Sun, L. (deposition date: 2025-03-18, release date: 2026-07-29)

• Primary citation: Schonbrunn, E.,Sun, L.; Late-stage functionalization with strain-release warheads enables tunable covalent inhibition; Science, 2026; DOI: 10.1126/science.adx7219

Experimental method

X-RAY DIFFRACTION (1.55 Å)