9NSO

Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-41060

This is a non-PDB format compatible entry.

Summary for 9NSO

• Entry DOI: 10.2210/pdb9nso/pdb
• Related: 9NSN
• Descriptor: DDB1- and CUL4-associated factor 1, WD repeat-containing protein 5, (4P)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-5-[(34E)-1-{(1P)-6-fluoro-3'-[4-fluoro-2-(trifluoromethyl)benzamido]-4'-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-1,33-dioxo-5,8,11,14,17,20,23,26,29-nonaoxa-2,32-diazapentatriacont-34-en-35-yl]-1H-pyrrole-3-carboxamide, ... (4 entities in total)
• Functional Keywords: e3 ligase, adaptor, protac, wdr, ternary complex, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 76208.39

Authors

Mabanglo, M.F.,Wilson, B.J.,Mamai, A.,Hoffer, L.,Al-awar, R.,Vedadi, M. (deposition date: 2025-03-17, release date: 2026-03-25)

• Primary citation: Mabanglo, M.F.,Vedadi, M.; Structural basis for the cooperative binding of DCAF1-PROTAC-WDR5 ternary complexes; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)