9NSN

Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-41059

This is a non-PDB format compatible entry.

Summary for 9NSN

• Entry DOI: 10.2210/pdb9nsn/pdb
• Related: 9NSO
• Descriptor: DDB1- and CUL4-associated factor 1, WD repeat-containing protein 5, N-{(1P)-5'-({(26E)-27-[(3P)-4-{[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]carbamoyl}-3-(4-chloro-2-fluorophenyl)-1H-pyrrol-2-yl]-25-oxo-3,6,9,12,15,18,21-heptaoxa-24-azaheptacos-26-en-1-yl}carbamoyl)-2'-fluoro-4-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carboxamide, ... (4 entities in total)
• Functional Keywords: e3 ligase, adaptor, protac, wdr, ternary complex, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 76119.28

Authors

Mabanglo, M.F.,Wilson, B.J.,Mamai, A.,Hoffer, L.,Al-awar, R.,Vedadi, M. (deposition date: 2025-03-17, release date: 2026-03-25)

• Primary citation: Mabanglo, M.F.,Vedadi, M.; Structural basis for the cooperative binding of DCAF1-PROTAC-WDR5 ternary complexes; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)