9NSB

Crystal structure of an MKP5 allosteric loop mutant, S446G, in complex with an allosteric inhibitor

Summary for 9NSB

• Entry DOI: 10.2210/pdb9nsb/pdb
• Descriptor: Dual specificity protein phosphatase 10, 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one (2 entities in total)
• Functional Keywords: mkp5, allosteric inhibitor, allosteric site, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 104833.09

Authors

Manjula, R.,Bennett, A.M.,Lolis, E. (deposition date: 2025-03-16, release date: 2025-07-30)

• Primary citation: Manjula, R.,Bennett, A.M.,Lolis, E.; Crystal structure of an MKP5 allosteric loop mutant, S446G, in complex with an allosteric inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)