9NQL

Cryo electron microscopic analysis of the adduct of syringolin analog with the Mtb 20S proteasome

This is a non-PDB format compatible entry.

Summary for 9NQL

• Entry DOI: 10.2210/pdb9nql/pdb
• EMDB information: 49668
• Descriptor: Proteasome subunit beta, Proteasome subunit alpha, methyl N-{[2-({(3Z,5R,8R)-5-[(1H-indol-3-yl)methyl]-2,7-dioxo-1,6-diazacyclododec-3-en-8-yl}amino)-2-oxoethyl]carbamoyl}-L-valinate (3 entities in total)
• Functional Keywords: proteasome inhibitor, mycobacterium tuberculosis, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Mycobacterium tuberculosis; More
• Total number of polymer chains: 28
• Total formula weight: 725212.28

Authors

Gu, X.,Yu, Z. (deposition date: 2025-03-12, release date: 2026-08-26)

• Primary citation: Gu, X.,Rowheder, P.J.,Yu, Z.,Mohapatra, A.,Lun, S.,Jiang, X.,Li, D.,Yan, N.L.,Detomasi, T.C.,Pomares, D.F.T.,Chen, Y.,Gestwicki, J.E.,Lin, G.,Bishai, W.R.,Ernst, J.D.,Cheng, Y.,Craik, C.S.,Sello, J.K.; Substrate Mimicry by Inhibitors of the Mycobacterium tuberculosis 20S Proteasome and Their Activity against Mycobacteria In Vitro and in Macrophages; Acs Chem.Biol., 2026; DOI: 10.1021/acschembio.6c00448

Experimental method

ELECTRON MICROSCOPY (2.16 Å)