9NPM

Composite map of three pairs of dimeric VRC36 Fabs bound to HIV-1 BG505.T332N DS-SOSIP.664 Env trimer

Summary for 9NPM

• Entry DOI: 10.2210/pdb9npm/pdb
• EMDB information: 49628
• Descriptor: HIV-1 BG505.T332N DS-SOSIP.664 Env glycoprotein gp120, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total)
• Functional Keywords: hiv-1, n-linked glycan, high mannose, broadly neutralizing antibody, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 18
• Total formula weight: 528984.18

Authors

Cheng, J.,Cale, E.M.,Longo, N.,Sutton, M.S.,Lei, H.,Huang, R.,Morton, A.J.,Lang, Z.C.,Morano, N.C.,Roark, R.S.,Becker, J.E.,Tsybovsky, Y.,Li, N.,Zhang, B.,Du, H.,Rubin, S.,Shapiro, L.,Pierson, T.C.,Doria-Rose, N.A.,Zhou, T.,Kwong, P.D. (deposition date: 2025-03-11, release date: 2026-08-19)

• Primary citation: Cheng, J.,Cale, E.M.,Longo, N.,Sutton, M.S.,Lei, H.,Huang, R.,Morton, A.J.,Lang, Z.C.,Morano, N.C.,Roark, R.S.,Becker, J.E.,Tsybovsky, Y.,Li, N.,Zhang, B.,Du, H.,Rubin, S.,Shapiro, L.,Pierson, T.C.,Doria-Rose, N.A.,Zhou, T.,Kwong, P.D.; Composite map of three pairs of dimeric VRC36 Fabs bound to HIV-1 BG505.T332N DS-SOSIP.664 Env trimer; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.59 Å)