9NNT

BET BRD4-BD1 in complex with peptide 6.1

Summary for 9NNT

Entry DOI	10.2210/pdb9nnt/pdb
Descriptor	Bromodomain-containing protein 4, peptide 6.1 (3 entities in total)
Functional Keywords	inhibitor, complex, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	47908.95
Authors	Jing, X. (deposition date: 2025-03-06, release date: 2026-02-11)
Primary citation	Jing, X.,Suh, J.,Maxwell, J.,Patel, K.,Norman, A.,Reid, X.J.,Deshpande, C.,Low, J.K.K.,Payne, R.J.,Passioura, T.,Mackay, J.P. The effect of peptide size on target affinity in mRNA display-derived macrocyclic peptides. Chem.Commun.(Camb.), 2026 Cited by PubMed Abstract: The large size of macrocyclic peptides discovered by mRNA display can hinder therapeutic development. Using size-restricted RaPID libraries and analysis of 40 published datasets, we show that potent binders are more reliably identified from libraries with at least nine randomised residues, providing guidance for mRNA display screen design. PubMed: 41614404 DOI: 10.1039/d5cc06167a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.59 Å)

Structure validation