9NN5

BET BRD4-BD1 in complex with peptide 9.2

Summary for 9NN5

• Entry DOI: 10.2210/pdb9nn5/pdb
• Descriptor: Bromodomain-containing protein 4, peptide 9.2 (3 entities in total)
• Functional Keywords: transcription regulator/inhibitor, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 16843.38

Authors

Jing, X.,Mackay, J.P. (deposition date: 2025-03-05, release date: 2026-02-11)

Primary citation

Jing, X.,Suh, J.,Maxwell, J.,Patel, K.,Norman, A.,Reid, X.J.,Deshpande, C.,Low, J.K.K.,Payne, R.J.,Passioura, T.,Mackay, J.P.
The effect of peptide size on target affinity in mRNA display-derived macrocyclic peptides.
Chem.Commun.(Camb.), 2026

PubMed Abstract: The large size of macrocyclic peptides discovered by mRNA display can hinder therapeutic development. Using size-restricted RaPID libraries and analysis of 40 published datasets, we show that potent binders are more reliably identified from libraries with at least nine randomised residues, providing guidance for mRNA display screen design.

PubMed: 41614404
DOI: 10.1039/d5cc06167a

Experimental method

X-RAY DIFFRACTION (1.47 Å)