9NMT

ML418 bound inwardly rectifying potassium channel Kir7.1 R162Q mutant

This is a non-PDB format compatible entry.

Summary for 9NMT

• Entry DOI: 10.2210/pdb9nmt/pdb
• EMDB information: 49555
• Descriptor: Inward rectifier potassium channel 13, propan-2-yl {1-[(5-chloro-8-hydroxyquinolin-7-yl)methyl]piperidin-4-yl}carbamate (2 entities in total)
• Functional Keywords: inwardly rectifying potassium channel kir7.1 channel blocker ml418, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 162539.43

Authors

Peisley, A.,Su, M.,Cone, R. (deposition date: 2025-03-04, release date: 2026-01-28)

• Primary citation: Peisley, A.,Su, M.,Cone, R.; ML418 Binds in the Pore of the Inward Rectifier Kir7.1 and Inhibits the Channel In Vivo to Reduce Food Intake and Body Weight; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.9 Å)