9NJY
Terminal two domains of ClfA002 with bound Fab of AZD7745
Summary for 9NJY
| Entry DOI | 10.2210/pdb9njy/pdb |
| Descriptor | Clumping factor A, Human antibody, heavy chain fragment, antigen binding, Human antibody, light chain, antigen binding, ... (5 entities in total) |
| Functional Keywords | staphylococcus aureus, virulence factors, monoclonal antibody, prophylactic treatment, immune system |
| Biological source | Staphylococcus aureus More |
| Total number of polymer chains | 3 |
| Total formula weight | 80496.20 |
| Authors | Oganesyan, V.Y. (deposition date: 2025-02-28, release date: 2025-07-30, Last modification date: 2025-10-08) |
| Primary citation | Tkaczyk, C.,Keren-Kaplan, T.,Gamson, A.,Warrener, P.,Semenova, E.,Rosenthal, K.,Barnes, A.,Ahani, B.,Sellman, B.R.,Podlaha, O.,Oganesyan, V. Structure of ClfA002 in Complex With Neutralizing Antibody AZD7745 Provides Insight into Its Broad Neutralization Mechanism in Staphylococcus aureus Infection. J.Infect.Dis., 232:e421-e430, 2025 Cited by PubMed Abstract: Complications due to Staphylococcus aureus infections are a major health concern as current therapies lack broad coverage; therefore, development of a broad neutralizing therapy is critical. We previously showed that a mAb combination comprising suvratoxumab and AZD7745 targeting respectively alpha toxin and clumping factor A (ClfA), two S. aureus virulence factors, provided broad strain coverage in a mouse model. To understand the basis for the broad strain coverage of AZD7745 the epitope was determined. Moreover, we surveyed a global collection of bacteremia isolates to study AZD7745 epitope conservation and neutralizing activity. PubMed: 40632825DOI: 10.1093/infdis/jiaf357 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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