9NIF

Cryo-EM structure of the PI3K alpha/KRas complex on POPC/POPS/PIP2 nanodiscs low-pass filtered to 5 angstroms

This is a non-PDB format compatible entry.

Summary for 9NIF

• Entry DOI: 10.2210/pdb9nif/pdb
• EMDB information: 49460
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Isoform 2B of GTPase KRas, (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1 ,2-DIYL DIBUTANOATE, ... (6 entities in total)
• Functional Keywords: lipid kinase, gtpase, oncoprotein, transferase-hydrolase complex, transferase/hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 151101.75

Authors

Torosyan, H.,Natalia, J.,Verba, K.A. (deposition date: 2025-02-26, release date: 2026-05-20)

• Primary citation: Torosyan, H.,Paul, M.D.,Maker, A.,Meyer, B.G.,Jura, N.,Verba, K.A.; Structures of the PI3K alpha /KRas complex on lipid bilayers reveal the molecular mechanism of PI3K alpha activation; Biorxiv, 2025; DOI: 10.1101/2025.03.22.644753

Experimental method

ELECTRON MICROSCOPY (5 Å)