9NI7

Cryo-EM structure of the Class 3 PI3K alpha/KRas complex on POPC/POPS nanodiscs

This is a non-PDB format compatible entry.

Summary for 9NI7

• Entry DOI: 10.2210/pdb9ni7/pdb
• EMDB information: 49455
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Isoform 2B of GTPase KRas, tert-butyl [2-(2-{[(2P)-2-{4-[4-(2-amino-2-oxoethyl)-2-fluoroanilino]thieno[2,3-d]pyridazin-7-yl}phenyl]oxy}ethoxy)ethyl]carbamate, ... (5 entities in total)
• Functional Keywords: lipid kinase, gtpase, oncoprotein, transferase-hydrolase complex, transferase/hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 150467.39

Authors

Torosyan, H.,Natalia, J.,Verba, K.A. (deposition date: 2025-02-25, release date: 2026-05-20)

• Primary citation: Torosyan, H.,Paul, M.D.,Maker, A.,Meyer, B.G.,Jura, N.,Verba, K.A.; Structures of the PI3K alpha /KRas complex on lipid bilayers reveal the molecular mechanism of PI3K alpha activation; Biorxiv, 2025; DOI: 10.1101/2025.03.22.644753

Experimental method

ELECTRON MICROSCOPY (3.05 Å)