9NF2

KRAS G12D Mutant KRAS 1-169 at 298 K bound to MRTX-1133 and GMPPNP

Summary for 9NF2

• Entry DOI: 10.2210/pdb9nf2/pdb
• Descriptor: Isoform 2B of GTPase KRas, 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: gtpase, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 19932.62

Authors

Xu, M.,Deck, S.L.,Milano, S.K.,Aplin, C.,Cerione, R.A. (deposition date: 2025-02-20, release date: 2026-02-25)

• Primary citation: Xu, M.,Deck, S.L.,Milano, S.K.,Aplin, C.,Cerione, R.A.; Room Temperature Structures of Oncogenic KRAS-G12D bound to MRTX-1133; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)