9NEO

TEAD2 YAP binding domain (YBD)

This is a non-PDB format compatible entry.

Summary for 9NEO

• Entry DOI: 10.2210/pdb9neo/pdb
• Descriptor: Transcriptional enhancer factor TEF-4, (3R)-3-ethenyl-3-(5-{3-[4-(trifluoromethyl)anilino]pyridin-2-yl}-1,3,4-oxadiazol-2-yl)pyrrolidin-2-one (2 entities in total)
• Functional Keywords: inhibitor, complex, transcriptional enhancer factor, tef-4, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 58814.22

Authors

Lee, C.C. (deposition date: 2025-02-20, release date: 2026-03-04)

• Primary citation: Orr, S.,Cao, J.,Han, X.,Fischer, K.,Villanueva, N.,Lee, C.C.,Do, Q.,Li, J.,Kim, S.,Pan, W.,Sund, S.,Pronk, B.,Mochalkin, I.,Huang, P.,Bunker, K.,Escoubet, L.; Discovery of a potent and orally bioavailable reversible oxadiazole TEAD inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.13 Å)