9NEM

Structure of Unc119-Farnesylated peptide complex

Summary for 9NEM

• Entry DOI: 10.2210/pdb9nem/pdb
• Descriptor: Protein unc-119 homolog A, FARNESYL (3 entities in total)
• Functional Keywords: unc119, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 139181.96

Authors

Srivastava, D.,Sebag, J.A.,Artemyev, N.O. (deposition date: 2025-02-20, release date: 2025-09-03)

Primary citation

Mittal, A.,Buscaglia, P.,Srivastava, D.,Artemyev, N.O.,Sebag, J.A.
Inhibition of Unc119b improves insulin sensitivity through potentiation of Rac1 activation in skeletal muscle and brown adipose tissue.
Mol Metab, 100:102230-102230, 2025

PubMed Abstract: A hallmark of type II diabetes is an impairment of the glucose transporter GLUT4 translocation to the plasma membrane of specialized cells in response to insulin. Identifying mechanisms involved in this defect is critical to developing treatments that restore insulin sensitivity. We previously identified a small molecule insulin sensitizer, C59, which improves insulin-stimulated GLUT4 translocation through binding to Unc119b, however, the role and mechanism of Unc119b-mediated regulation of GLUT4 trafficking is unknown.

PubMed: 40754229
DOI: 10.1016/j.molmet.2025.102230

Experimental method

X-RAY DIFFRACTION (2.49 Å)