9ND5

JAK2 pseudokinase domain in complex with diaminotriazole covalent inhibitor

This is a non-PDB format compatible entry.

Summary for 9ND5

• Entry DOI: 10.2210/pdb9nd5/pdb
• Related: 9ND3
• Descriptor: Tyrosine-protein kinase JAK2, 4-{[5-amino-1-(3-{[fluorodi(hydroxy)-lambda~4~-sulfanyl]oxy}benzoyl)-1H-1,2,4-triazol-3-yl]amino}benzene-1-sulfonamide (3 entities in total)
• Functional Keywords: jak2 kinase, pseudokinase domain, allosteric inhibitors, pseudokinase domain inhibitors, covalent inhibitors, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 32885.64

Authors

Primi, M.C.,Eck, M.J. (deposition date: 2025-02-17, release date: 2025-11-05)

• Primary citation: Primi, M.C.,Eck, M.J.; JAK2 pseudokinase domain in complex with diaminotriazole covalent inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)