9ND5
JAK2 pseudokinase domain in complex with diaminotriazole covalent inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK2 | polymer | 280 | 32427.2 | 1 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 2,JAK-2 |
| 2 | B (A) | 4-{[5-amino-1-(3-{[fluorodi(hydroxy)-lambda~4~-sulfanyl]oxy}benzoyl)-1H-1,2,4-triazol-3-yl]amino}benzene-1-sulfonamide | non-polymer | 458.4 | 1 | Chemie (A1BXA) | |||
| 3 | C (A) | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A: 536 - 809 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| His 794 | Phe 794 | conflict |
| His 810 | - | expression tag |
| His 811 | - | expression tag |
| His 812 | - | expression tag |
| His 813 | - | expression tag |
| His 814 | - | expression tag |
| His 815 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32427.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 458.4 | |
| All* | Total formula weight | 32885.6 |
