9NCT

Crystal Structure of WDR5 in complex with Triazole-Based Inhibitors

This is a non-PDB format compatible entry.

Summary for 9NCT

• Entry DOI: 10.2210/pdb9nct/pdb
• Descriptor: WD repeat-containing protein 5, 4-({6-cyclopropyl-8-[(2-methyl-1H-imidazol-1-yl)methyl]-4,5-dihydro-3H-naphtho[1,2-d][1,2,3]triazol-3-yl}methyl)-2-methoxybenzonitrile (3 entities in total)
• Functional Keywords: wdr5, inhibitor, structural protein, structural protein-inhibitor complex, structural protein/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 95049.23

Authors

Goins, C.M.,Stauffer, S.R. (deposition date: 2025-02-17, release date: 2025-08-13)

• Primary citation: Coker, J.A.,Martinez, S.R.,Han, S.H.,Sloan, A.R.,Gupta, A.K.,Bukenya, G.,Polzer, P.,Ramos, J.H.,Rico, E.,Rico, A.,Lindsey, A.A.,Navadgi, T.,Reitz, N.,Romigh, T.,Goins, C.M.,Hubert, C.G.,Wang, N.S.,Cheng, F.R.,Alvarado, J.,Sprowls, S.A.,Lathia, J.D.,Stauffer, S.R.; Development and Characterization of Triazole-Based WDR5 Inhibitors for the Treatment of Glioblastoma; Biorxiv, 2025; DOI: 10.1101/2025.07.29.667410

Experimental method

X-RAY DIFFRACTION (2.11 Å)