9NCD

Crystal structure of the peanut allergen Ara h 9 with bound Fab IGX-3103 and antiFab nanobody

Summary for 9NCD

Entry DOI	10.2210/pdb9ncd/pdb
Descriptor	Fab IGX-3103 light chain, Fab IGX-3103 heavy chain, anti Kappa light chain nanobody (antiFab), ... (9 entities in total)
Functional Keywords	allergy, antibody complex, peanut, allergen
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	95907.49
Authors	Pedersen, L.C.,Mueller, G.A. (deposition date: 2025-02-15, release date: 2026-02-18)
Primary citation	Leighton, G.O.,Pedersen, L.C.,Min, J.,Creeks, P.,Gabel, S.A.,Perera, L.,Randall, T.A.,Petrovich, R.M.,Hamilton, R.G.,Croote, D.,Mueller, G.A. A Human Monoclonal Antibody Displays Promiscuous Binding to Multiple Type 1 nsLTP Allergens. J Investig Allergol Clin Immunol, :0-0, 2026 Cited by PubMed Abstract: Nonspecific lipid transfer proteins (nsLTPs) are frequently cross-reactive allergens that hamper diagnosis and avoidance. It is challenging to distinguish cross-reactivity from cosensitization with polyclonal serum owing to the presence of a few promiscuous antibodies or many highly specific antibodies. Objective: We hypothesized that a robust analysis of more human monoclonal antibodies (mAbs) would enable us to compare crossreactivity with cosensitization. PubMed: 41661651 DOI: 10.18176/jiaci.1143 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation