9NB3

Cryo-EM structure of quaternary complex of human phosphoribosylglycinamidine synthase with thioester intermediate bound (at glutaminase site) and AMPPNP and FGAR (at synthase site).

Summary for 9NB3

• Entry DOI: 10.2210/pdb9nb3/pdb
• EMDB information: 49207
• Descriptor: Phosphoribosylformylglycinamidine synthase, N-(N-FORMYLGLYCYL)-5-O-PHOSPHONO-BETA-D-RIBOFURANOSYLAMINE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (7 entities in total)
• Functional Keywords: quaternary complex phosphoribosylglycinamidine synthase fgar thioester amppnp, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 149962.31

Authors

Sharma, N.,French, J.B. (deposition date: 2025-02-13, release date: 2026-02-25)

• Primary citation: Sharma, N.,Zhou, W.,French, J.B.; Structural and molecular basis for allosteric regulation and catalytic coupling of human phosphoribosylformylglycinamidine synthase; Nat Commun, 2026; DOI: 10.1038/s41467-026-69423-y

Experimental method

ELECTRON MICROSCOPY (3.19 Å)