9N7F

HsSTING with cGAMP/C53/DCA

Summary for 9N7F

• Entry DOI: 10.2210/pdb9n7f/pdb
• EMDB information: 49094
• Descriptor: Stimulator of interferon genes protein, 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, cGAMP (3 entities in total)
• Functional Keywords: innate immunity, membrane protein, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 163314.58

Authors

Gharpure, A.,Ward, A.B. (deposition date: 2025-02-05, release date: 2026-02-18)

• Primary citation: Yang, X.,Zhang, X.,Li, W.,Gharpure, A.,Hansel, A.,Tillack, A.,Wu, C.,Hsieh, Y.,Sulpizio, A.,Dikiy, S.,Zhao, X.,Forli, S.,Ward, A.B.,Parker, C.G.,Hang, H.C.; Microbiota-derived secondary bile acids promote STING activation and antitumor activity; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.93 Å)