9N12

Cryo-EM structure of HCoV-HKU1 glycoprotein (mutant T31VPR34 to GGGG)

Summary for 9N12

• Entry DOI: 10.2210/pdb9n12/pdb
• EMDB information: 48803
• Descriptor: Spike glycoprotein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: hcov-hku1 spike glycoprotein ectodomain, proline stablized, viral protein
• Biological source: Human coronavirus HKU1
• Total number of polymer chains: 3
• Total formula weight: 470704.40

Authors

Jin, M.,Rini, J.M. (deposition date: 2025-01-24, release date: 2025-05-14)

• Primary citation: Jin, M.,Hassan, Z.,Li, Z.,Liu, Y.,Marakhovskaia, A.,Wong, A.H.M.,Forman, A.,Nitz, M.,Gilbert, M.,Yu, H.,Chen, X.,Rini, J.M.; Human coronavirus HKU1 spike structures reveal the basis for sialoglycan specificity and carbohydrate-promoted conformational changes; Nat Commun, 16:4158-, 2025; DOI: 10.1038/s41467-025-59137-y

Experimental method

ELECTRON MICROSCOPY (3.18 Å)