9N0V
Crystal structure of the HIV capsid hexamer bound to the small molecule long-acting inhibitor, KFA-027
This is a non-PDB format compatible entry.
Summary for 9N0V
| Entry DOI | 10.2210/pdb9n0v/pdb |
| Descriptor | Capsid protein p24, N-[(1S)-1-{(3M)-3-[4-chloro-3-(methanesulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl]-6-[3-(methanesulfonyl)-3-methylbut-1-yn-1-yl]pyridin-2-yl}-2-phenylethyl]-2-[(3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl]acetamide (2 entities in total) |
| Functional Keywords | hiv capsid hexamer, capsid inhibitor, long-acting inhibitor, viral protein |
| Biological source | Human immunodeficiency virus 1 |
| Total number of polymer chains | 4 |
| Total formula weight | 101273.13 |
| Authors | |
| Primary citation | Dinh, T.T.,Kvaratskhelia, M. Delineating structural functionalities of Lenacapavir amenable to modifications for targeting emerging drug-resistant HIV-1 capsid variants To Be Published, |
| Experimental method | X-RAY DIFFRACTION (2.98 Å) |
Structure validation
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