9MZ4

Structure of human endothelial nitric oxide synthase heme domain bound 7-(3-(aminomethyl)-4-(cyclopropylmethoxy)phenyl)-6-fluoro-4-methylquinolin-2-amine

This is a non-PDB format compatible entry.

Summary for 9MZ4

• Entry DOI: 10.2210/pdb9mz4/pdb
• Descriptor: Nitric oxide synthase 3, CALCIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... (11 entities in total)
• Functional Keywords: nitric oxide synthase inhibitor binding, oxidoreductase-inhibitor complex, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 205704.24

Authors

Li, H.,Poulos, T.L. (deposition date: 2025-01-22, release date: 2025-12-03)

• Primary citation: Ansari, A.,Rathnayake, A.D.,Li, H.,Hardy, C.D.,Poulos, T.L.,Silverman, R.B.; Design and synthesis of 7-aryl-6-fluoro-2-aminoquinolines as potent and highly selective human neuronal nitric oxide synthase inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.94 Å)