9MTE

CryoEM structure of extracellular domain of human HER2 complexed with two nano-bodies 27A05 and 47D05

Summary for 9MTE

• Entry DOI: 10.2210/pdb9mte/pdb
• EMDB information: 48606
• Descriptor: VHH nanobody 27A05, VHH nanobody 47D05, Receptor tyrosine-protein kinase erbB-2 (3 entities in total)
• Functional Keywords: nanobodies, vhh, her2, complex, cancer, transferase, transferase-immune system complex, transferase/immune system
• Biological source: Lama glama (llama); More
• Total number of polymer chains: 3
• Total formula weight: 99473.90

Authors

Bruch, E.M.,Rak, A. (deposition date: 2025-01-11, release date: 2025-11-19)

• Primary citation: De Tavernier, E.,Kim, P.,Bruch, E.M.,Cortez-Retamozo, V.,Rak, A.,Vintem, A.P.B.; TPP-45142, an Anti-HER2 T-cell Engager Designed for Selective HER2-Low Cancer Immune TherapyImmunotherapy; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.66 Å)