9MK6

Cryo-EM structure of human NBCn2 bound to Compound 38J

This is a non-PDB format compatible entry.

Summary for 9MK6

• Entry DOI: 10.2210/pdb9mk6/pdb
• EMDB information: 48320
• Descriptor: Sodium-driven chloride bicarbonate exchanger, CHOLESTEROL, ethyl [(8R)-2-{[(3-methylphenyl)methyl]amino}-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]acetate, ... (4 entities in total)
• Functional Keywords: transmembrane, transport protein, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 226201.09

Authors

Yang, S.,Capper, M.J.,Zilberg, G.,Warren, A.L.,Wacker, D. (deposition date: 2024-12-16, release date: 2026-08-05)

• Primary citation: Yang, S.,Zhao, Y.,Vatansever, S.,Zilberg, G.,Capper, M.J.,Zhang, J.,Stamos, J.,Hutchinson, K.,Warren, A.L.,Stone, A.C.,Abbassi, A.,Purisic, E.,Ho, L.,Li, A.,Dai, J.,Schlessinger, A.,Zhang, B.,Wacker, D.; Structural insights enable drug discovery for the neuronal NBCn2 carbonate transporter; Nat Commun, 2026; DOI: 10.1038/s41467-026-75444-4

Experimental method

ELECTRON MICROSCOPY (3.24 Å)