9MHG

Cryo EM reconstruction of PI3KC3-C1 in complex with Human RAB1A(Q70L), VPS34 kinase domain in the inactive conformation

9MHG の概要

• エントリーDOI: 10.2210/pdb9mhg/pdb
• EMDBエントリー: 48277
• 分子名称: Phosphoinositide 3-kinase regulatory subunit 4, Phosphatidylinositol 3-kinase catalytic subunit type 3, Beclin 1-associated autophagy-related key regulator, ... (8 entities in total)
• 機能のキーワード: complex, gtpase, gtp-binding, autophagy, kinase, lipid kinase, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 394359.08

構造登録者

Cook, A.S.I.,Hurley, J.H.,Chen, M. (登録日: 2024-12-11, 公開日: 2025-02-12)

• 主引用文献: Cook, A.S.I.,Chen, M.,Ngyuen, T.N.,Claveras-Cabezudo, A.,Khuu, G.,Rao, S.,Garcia, S.N.,Yang, M.,Iavarone, A.T.,Ren, X.,Lazarou, M.,Hummer, G.,Hurley, J.H.; Structural pathway for class III PI 3-kinase activation by the myristoylated GTPbinding pseudokinase VPS15; To Be Published,

実験手法

ELECTRON MICROSCOPY (3.2 Å)