9M2W

The cryo-EM structure of 26S proteasome-Midnolin complex in the MD state

Summary for 9M2W

Entry DOI	10.2210/pdb9m2w/pdb
Related	9UF8 9UG9
EMDB information	62695 63592
Descriptor	26S proteasome regulatory subunit 7, Proteasome subunit alpha type-7, Proteasome subunit alpha type-5, ... (36 entities in total)
Functional Keywords	midnolin, 26s proteasome, complex, hydrolase, md state
Biological source	Homo sapiens More
Total number of polymer chains	48
Total formula weight	1718879.88
Authors	Wang, H.Y.,Xu, W.Q. (deposition date: 2025-02-28, release date: 2025-09-10, Last modification date: 2026-07-01)
Primary citation	Wang, H.,Zheng, Y.,Wang, T.,Zhang, X.,Wang, P.,Wei, C.,Li, H.,Wang, Q.,Zhang, L.,Ke, X.,Xu, W. Structure-based engineering of the midnolin-proteasome pathway for targeted protein degradation. Protein Cell, 17:83-88, 2026 Cited by PubMed: 40851512 DOI: 10.1093/procel/pwaf069 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.31 Å)

Structure validation