9LYV

structure of prrx bound to DNA

Summary for 9LYV

• Entry DOI: 10.2210/pdb9lyv/pdb
• Descriptor: Paired mesoderm homeobox protein 2, DNA (5'-D(*TP*AP*CP*TP*AP*AP*TP*TP*AP*GP*TP*A)-3') (3 entities in total)
• Functional Keywords: dna binding, dna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 9
• Total formula weight: 44574.85

Authors

Dong, C.,Yan, X.J.,Guo, S.M.,Huang, Y.L. (deposition date: 2025-02-21, release date: 2026-01-14, Last modification date: 2026-02-18)

Primary citation

Guo, S.,Pan, T.,Yan, X.,Cheng, Y.,Du, R.,Liu, Q.,Huang, Y.,Zhuo, Y.,Zhao, Y.,Tian, D.,Shi, X.,Qiang, T.,Cao, X.,Tang, X.,Korinek, V.,Huang, D.,Zhou, B.,Wang, J.W.,Dong, C.,Qi, Y.,Shen, Y.,Yu, Y.
Differential Impact of Recruited and Resident Macrophages on Hypoxia-Induced Pulmonary Hypertension.
Circ Res, 138:-, 2026

PubMed Abstract: Pulmonary interstitial macrophages can be divided into 2 distinct subsets with different origins: resident macrophages (resMФs) and recruited macrophages (recMФs). However, their specific roles in pulmonary arterial hypertension remain unclear.

PubMed: 41473960
DOI: 10.1161/CIRCRESAHA.125.326472

Experimental method

X-RAY DIFFRACTION (1.52 Å)