9LWQ

Cryo-EM structure of PI3Kalpha in complex with compound UCL-TRO-1938

Summary for 9LWQ

• Entry DOI: 10.2210/pdb9lwq/pdb
• EMDB information: 63456
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 1-[7-[[2-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyridin-4-yl]amino]-2,3-dihydroindol-1-yl]ethanone (3 entities in total)
• Functional Keywords: phosphoinositide 3-kinase, drug target, activator, allosteric binding pocket, cytosolic protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 211902.36

Authors

Liu, X.,Zhou, Q. (deposition date: 2025-02-16, release date: 2025-10-01)

• Primary citation: Liu, X.,Zhou, Q.,Chen, Y.,Han, W.,Li, J.,Mai, Y.,Wang, M.W.; Molecular mechanisms of PI3K alpha activation by small-molecule activator 1938 and cancer-specific mutation H1047R.; Cell Discov, 11:77-77, 2025; PubMed: 40968123; DOI: 10.1038/s41421-025-00833-w

Experimental method

ELECTRON MICROSCOPY (3.17 Å)