9LLH

Cryo-EM structure of D1R-Gs in complex with de novo designed agonist-positive allosteric GEM targeting TM5/6/7

Summary for 9LLH

• Entry DOI: 10.2210/pdb9llh/pdb
• EMDB information: 63202
• Descriptor: Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: gpcr, gem, gpcr exoframe modulator, d1r, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 200774.44

Authors

Guo, J.,Zhou, Y.,Cheng, S.,Zhang, Y. (deposition date: 2025-01-17, release date: 2026-03-04)

• Primary citation: Cheng, S.,Guo, J.,Zhou, Y.,Zhang, Y.; GPCR exoframe modulator; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.73 Å)