9L61

Crystal Structure of BRD2 BD2 domain in complex with small molecule inhibitor Mivebresib ABBV-075

Summary for 9L61

• Entry DOI: 10.2210/pdb9l61/pdb
• Descriptor: Bromodomain-containing protein 2, N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide (3 entities in total)
• Functional Keywords: bromodomain, inhibitor, small molecule, drug discovery, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 30977.16

Authors

Jwala, N.,Vijayshankar, N.,Thomas, A.,NarasimhaRao, K. (deposition date: 2024-12-23, release date: 2025-12-24)

• Primary citation: Jwala, N.,NarasimhaRao, K.; Crystal Structure of BRD2 BD2 domain in complex with small molecule inhibitor Mivebresib ABBV-075; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)