9L60

Gi-bound kappa opioid receptor in complex with dynorphin and positive allosteric modulator MPAM-15

Summary for 9L60

Entry DOI	10.2210/pdb9l60/pdb
EMDB information	62849
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
Functional Keywords	complex, gpcr, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	134940.18
Authors	Zhuang, Y.,Wang, Y.,Xu, Y.,Luo, P.,Xu, H.E. (deposition date: 2024-12-23, release date: 2025-12-31)
Primary citation	Wang, Y.,Xu, Y.,Xu, H.E.,Zhuang, Y. Structure-based design of an opioid receptor modulator for enhanced morphine analgesia To Be Published,
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation