9L00

structure of hZnT1-CDDO-ME complex

This is a non-PDB format compatible entry.

Summary for 9L00

• Entry DOI: 10.2210/pdb9l00/pdb
• EMDB information: 62681
• Descriptor: Proton-coupled zinc antiporter SLC30A1, methyl (4aS,6aR,6bS,8aR,12aS,14aS,14bS}-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-bis(oxidanylidene)-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylate (2 entities in total)
• Functional Keywords: transporter, zn, cancer, drug target, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 111736.59

Authors

Xu, B.,Wang, Y. (deposition date: 2024-12-11, release date: 2025-09-24, Last modification date: 2026-01-07)

• Primary citation: Wang, Y.,Liang, Q.,Liang, S.,Shan, Y.,Shi, S.,Zhou, X.,Wang, Z.,Xu, Z.,Pei, D.,Zhang, M.,Lou, Z.,Xu, B.,Ye, S.; Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer.; Protein Cell, 16:991-996, 2025; PubMed: 40470835; DOI: 10.1093/procel/pwaf044

Experimental method

ELECTRON MICROSCOPY (3.78 Å)