9KZW

structure of hZnT1 in apo state

Summary for 9KZW

• Entry DOI: 10.2210/pdb9kzw/pdb
• EMDB information: 62677
• Descriptor: Proton-coupled zinc antiporter SLC30A1 (1 entity in total)
• Functional Keywords: transporter, zn, cancer, drug target, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 110725.21

Authors

Xu, B.,Wang, Y. (deposition date: 2024-12-11, release date: 2025-09-24, Last modification date: 2026-01-07)

• Primary citation: Wang, Y.,Liang, Q.,Liang, S.,Shan, Y.,Shi, S.,Zhou, X.,Wang, Z.,Xu, Z.,Pei, D.,Zhang, M.,Lou, Z.,Xu, B.,Ye, S.; Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer.; Protein Cell, 16:991-996, 2025; PubMed: 40470835; DOI: 10.1093/procel/pwaf044

Experimental method

ELECTRON MICROSCOPY (3 Å)