9KLW

Crystal structure of EGFR T790M, L858R mutant complexed with N-[4-[4-amino-6-ethynyl-5-(3-quinolyl)pyrrolo[2,3-d]pyrimidin-7-yl]norbornan-1-yl]pyrimidine-5-carboxamide

This is a non-PDB format compatible entry.

Summary for 9KLW

• Entry DOI: 10.2210/pdb9klw/pdb
• Descriptor: Epidermal growth factor receptor, N-[4-[4-amino-6-ethynyl-5-(3-quinolyl)pyrrolo[2,3-d]pyrimidin-7-yl]norbornan-1-yl]pyrimidine-5-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: tki, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38232.27

Authors

Suzuki, T.,Kasuga, H.,Yamamoto, F. (deposition date: 2024-11-15, release date: 2025-09-24)

• Primary citation: Kasuga, H.,Kataoka, Y.,Yamamoto, F.,Tsuji, S.,Miyamoto, R.,Suzuki, T.,Mizuarai, S.; Discovery of TAS3351, a brain-penetrable 4th generation EGFR-TKI overcoming T790M and C797S resistant mutations.; Res Sq, 2025; DOI: 10.21203/rs.3.rs-6573462/v1

Experimental method

X-RAY DIFFRACTION (2.67 Å)